ISCCM, PUNE BRANCH Research Committee
Membership of the Society shall be of 7 categories viz
- Dr. P K Joshi – Chairman, ISCCM Pune
- Dr. Sameer Jog – Co ordinator
- Dr. Shirish Prayag
- Dr. Kapil Zirpe
- Dr. Subhal Dixit
- Dr. Jignesh Shah
- Dr. Kayanoosh Kadapatti
IPRI (ISCCM Pune Research Initiative)
After the grand success of 18th National Annual Congress in February 2012, ISCCM Pune branch decided to initiate something long lasting, impact making activity in the form of research activity which is original and relevant to Indian context. Thus in July 2012, a separate research section of ISCCM Pune branch was established which got the acronym IPRI (ISCCM Pune Research Initiative)
Since Dengue infection is very much prevalent in Pune area and having many unanswered questions in its management in ICU, we decided to take this subject as our first research project.
DIMODS study
Background
Dengue infection is a common tropical infection in western Maharashtra. There has been an increase in the occurrence of severe dengue infection over the last 20 years in this region. Though the overall mortality of the infection is reported between 1.5 to 10 % in the published literature (Data predominantly from non Indian centres) we as Indian physicians really do not know the exact numbers. The manifestation of Severe Dengue infections are varied and include Shock, ARDS, Hepatitis, Encephalopathy, Myocarditis, Polyserocitis and coagulopathy. Unfortunately exact morbidity in terms of organ dysfunction/ disability is also not well studied in the Indian context. One pediatric study and several epidemiological studies in patients with severe dengue have shown that the development of multiple organ dysfunction in these patients is associated with higher mortality rates. Unfortunately precise diagnostic and management guidelines of this disease are lacking especially in the era of Modern Intensive Care. Hence on this background Indian Society of Critical Care Medicine- Pune Branch has taken an initiative in this study. Data from 3 of the ICUs from Pune has been published in Journal of Critical Care in 2010 but that study was more of retrospective data collection and interpretation. The proposed study will be prospective observational multicentric study
Aims and Objectives
- To study the morbidity and mortality of Severe Dengue Infection related MODS especially in the setting of Modern ICU care in the organ support therapiese
- To study the risk factors associated with morbidity and mortality
- To study the effect of various treatment strategies commonly recommended and practiced on the morbidity and mortality
Study Details
This is prospective observational multicentric study planned to conduct in 17 ICUs in Pune from 20th July 2012 to 1st December 2012.
Inclusion Criteria
- Adult > 18 years
- Confirmed diagnosis of Dengue Infection by IgM positive OR NS-1 antigen Positive OR Dengue PCR positive
- At least one Documented Non Hematological Organ Dysfunction by SOFA criteria
Exclusion Criteria
- ICU admission or study enrollment after 120 hours of first NHOD (e.g.) treated in periphery for 5 days now shifted to study ICU for Ventilator Associated Pneumonia or Hemodialysis
- Pregnancy
- Confounding diagnosis (Concurrent Malaria /Leptospira /Ricketssia/ Bacterial sepsis)
